What is Profhilo? How is it Different from Sculptra?

Key takeaway

• Profhilo is a next-generation collagen biostimulator composed of highly concentrated Hyaluronic Acid (HA). It is developed using patented NAHYCO® technology, allowing the product to spread evenly within the skin and stimulate collagen production effectively.
• Profhilo is ideal for individuals experiencing skin laxity, fine lines, reduced elasticity, or acne scars, especially those who want to improve skin quality without altering facial structure. It can also be combined with Sculptra or Radiesse to enhance overall results.
• The standard treatment protocol involves 2 sessions spaced 1 month apart. The procedure involves minimal discomfort, requires no downtime, and results become visible within 1-2 months, lasting approximately 6-12 months.

What is Profhilo?

Profhilo is an injectable treatment designed to stimulate new collagen production. As we age, collagen levels decline, leading to skin laxity, reduced elasticity, and wrinkles. Profhilo works by stimulating and repairing skin cells, particularly fibroblasts, which are responsible for collagen production.

What Does Profhilo Contain and How Does It Work?

Profhilo is made from Hyaluronic Acid, but with a unique patented process called NAHYCO® technology. This process uses thermal energy to bind two different molecular weights of HA into a special structure known as Hybrid Cooperative Complex (HCC).

This structure contains one of the highest concentrations of HA on the market, yet remains fluid and highly spreadable. Unlike traditional fillers, it does not form lumps and is specifically designed to stimulate collagen production, rather than add volume.

How is Profhilo Different from HA Fillers?

Hyaluronic Acid injectables generally fall into two categories

1. Cross-linked HA

These are traditional dermal fillers (e.g., Restylane, Juvederm, Belotero) where HA molecules are chemically bonded to create a gel structure. They are used for volume restoration and contouring, but do not significantly stimulate long-term collagen.

2. Non-crosslinked HA

These are typically used in skin boosters or mesotherapy, providing temporary hydration but are quickly broken down by the body within 24-48 hours.

Which Category Does Profhilo Belong To?

Profhilo is considered a unique category. It is not a traditional filler and not a simple skin booster. It is a special form of non-crosslinked HA, enhanced with NAHYCO® technology to remain longer in the skin without chemical crosslinkers like BDDE. This reduces risks such as vascular occlusion and allows Profhilo to effectively stimulate collagen more than standard HA products.

Expected Results from Profhilo

Profhilo delivers both hydration from HA and long-term improvement from collagen and elastin stimulation

• Smoother, plumper, and more refined skin
• Improved elasticity and firmness
• Long-term collagen stimulation (also beneficial for acne scars and neck wrinkles)
• Increased hydration and natural glow

Why Choose Profhilo Among Other Biostimulators?

While there are many biostimulators available, most do not offer significantly different results compared to Sculptra or Radiesse. Profhilo, however, provides a distinct approach and works well as a complementary treatment to enhance overall skin quality.

Profhilo vs Sculptra vs Radiesse

Profhilo

Stimulates collagen in both superficial and deep layers. Improves hydration, smoothness, and elasticity without adding volume or lifting.

Sculptra

Targets deep dermal layers, improving structural firmness and skin thickness. Can provide lifting and volume when used in higher amounts.

Radiesse

Offers immediate volumizing effects along with long-term collagen stimulation.

Profhilo focuses on skin quality and hydration across all layers, while Sculptra and Radiesse focus more on deep structural support and volume.

Profhilo vs Rejuran: Which is Better?

The choice depends on your skin concern

• Rejuran: Best for surface-level issues such as pores, acne marks, and skin texture
• Profhilo: Ideal for skin laxity, dehydration, and elasticity, improving deeper skin structure without altering facial shape

Who is Profhilo Suitable For?

• Individuals with skin laxity and reduced elasticity without volume loss
• Those who want smoother, more hydrated, youthful-looking skin
• Patients who have already undergone Sculptra or Radiesse and want to improve superficial skin quality
• Those seeking glow, hydration, and refined texture
• Individuals with acne scars (can be combined with other treatments)

Treatment Areas

• Face
• Acne scars
• Neck
• Hands
• Areas with skin laxity on the body

Recommended Treatment Plan

The standard protocol is 2 sessions spaced 1 month apart. Results become more visible after the second month and last 6-12 months. Maintenance treatments are recommended every 6-12 months.

Injection Technique & Number of Sessions

Profhilo is suitable for those who are concerned about injections, as it can be administered using the BAP (Bio Aesthetic Points) technique, with only 5 injection points per side of the face.

• Typically uses 1-2 syringes per session
• Recommended 2-3 sessions for optimal collagen stimulation

When Will You See Results?

• Initial improvements can be seen after 1 month
• More noticeable results after 2 months
• Effects last approximately 6-12 months, depending on individual response

For long-term skin rejuvenation, treatments can be repeated every 6 months.

Are There Any Side Effects of Profhilo?

Profhilo is considered a safe treatment with minimal side effects. After the injection, you may experience mild needle marks, small bumps, or slight bruising at the injection sites. These effects are temporary and typically resolve on their own within 5-7 days. You can continue your daily activities as normal, as no downtime is required.

Why Choose Profhilo at DSK Clinic?

“Different techniques deliver different results only at DSK.”

Profhilo treatment requires a deep understanding of skin conditions and precise injection techniques. Incorrect technique, wrong injection depth, or lack of personalized planning may lead to suboptimal results.

At DSK Clinic, you can feel confident in your treatment. We are one of only a few clinics in Thailand where every doctor has been trained in advanced Profhilo techniques through private sessions with global expert Dr. Ofir Artzi one of the early pioneers of Profhilo and a renowned international professor in dermatology, aesthetics, laser treatments, and acne scar management.

This advanced training allows our medical team to fully customize each treatment, maximizing the potential of Profhilo based on the root cause of each patient’s skin concerns.

Comprehensive Treatment Approach at DSK Clinic

At DSK Clinic, we offer a full range of technologies to address all causes of skin aging and acne scars, including

• Ulthera SPT
• Red Touch
• Pro Laser
• Picosecond Laser

Not every concern is best treated with Profhilo alone. Our doctors carefully assess each case and select the most appropriate combination of treatments for optimal results. We believe that every treatment should begin with proper analysis and personalized planning from choosing the right technology to tailoring techniques for each individual. This philosophy is at the core of DSK Clinic and ensures highly satisfying, natural-looking results.

Profhilo Price

The cost of Profhilo treatment varies depending on individual skin conditions, degree of laxity, and the amount of product required. At DSK Clinic, we recommend a personalized consultation with our doctors to assess your skin and design the most suitable, safe, and cost-effective treatment plan.

Summary

Profhilo is one of the latest innovations in collagen biostimulation, introduced in Thailand in late 2024. Its unique formulation of Hyaluronic Acid using NAHYCO® technology allows it to stimulate collagen in both superficial and deep skin layers. Unlike Sculptra and Radiesse, which primarily target deeper layers, Profhilo improves overall skin quality resulting in smoother, firmer, more hydrated, and youthful-looking skin.

It is ideal for individuals with skin laxity, fine lines, and acne scars who want to improve their skin without altering facial structure, with results lasting 6-12 months. Beyond the product itself, doctor expertise is the key factor at DSK Clinic. Our medical team continuously advances their knowledge on a global level. Recently, our doctors attended the IMCAS World Congress in Paris, one of the most prestigious international aesthetic conferences.

Notably, Dr. Porsche was invited as a speaker representing Thailand to share advanced techniques in using Profhilo for acne scar treatment. This recognition reflects our commitment not only to selecting the best innovations, but also to delivering world-class treatment techniques for the most precise and effective results. Our Thai and English speaking medical team delivers professional, personalized care with seamless communication at every step. Book your appointment or consultation via

• Inbox  : https ://m.me/DSKclinic
• Line  : @dskinclinic (with @)
• WhatsApp  : +66 92 612 2779

FAQs About Profhilo

Is Profhilo painful? How long does swelling last?

The treatment involves minimal discomfort, as it uses the BAP technique with only 5 injection points per side. Small bumps may appear after injection, similar to mosquito bites, but typically subside within 12-24 hours (in some cases up to 2-3 days). No downtime is required.

Is Profhilo a type of filler?

No. Although Profhilo contains Hyaluronic Acid (HA), it is not a traditional dermal filler. It does not add volume or reshape the face. Instead, it acts as a biostimulator, promoting collagen and elastin production to improve skin firmness and elasticity.

When can I do laser or HIFU/Ulthera after Profhilo?

It is recommended to wait 2-4 weeks after Profhilo injections before undergoing energy-based treatments such as laser, HIFU, or Ulthera. This allows the product to fully integrate and work effectively without interference.